About Us - Comprehensive Technical Platform
About Us - Comprehensive Technical Platform

ABOUT US

Our Mission, Vision, and Values

使命 Mission:

安必进生物致力于为 IVD 行业提供创新且易于应用的生物材料。

At Ambigen Biotech, we are dedicated to providing innovative, easy-to-apply biomaterials for the IVD industry.

愿景 Vision:

通过与分子设计、功能修饰和免疫标记领域的专家合作,我们推动变革性突破,确保在各种实验室环境中实现一致且可靠的结果。

By collaborating with experts in molecular design, functional modification, and immunoassay labeling, we drive transformative breakthroughs that deliver consistent, reliable results across diverse laboratory environments.

价值观 Values:

秉持共同的愿景,我们致力于推动行业进步,鼓励创新,并为人类、技术及更广泛的医疗生态系统创造长期价值。

United by a shared vision, we are devoted to advancing the industry, encouraging innovation, and creating long-term value for people, technology, and the broader healthcare ecosystem.

Fermentation bottles
Fermentation equipment

R&D PIPELINE-- AUTOIMMUNE ANTIGENS

Category Antigens
Nuclear Antigens dsDNA (Manufacturing), Sm (Developing), RNP (Developing), SSA60, SSA52 (Developing), SSB, Jo-1 (Developing), CENP-B (Manufacturing), PCNA (Manufacturing), C1q (Manufacturing), Nucleosome, Histone (Developing), Rib P, scl-70, pm/scl 100
Phospholipid Syndrome aCL (Developing), β2GP1 (Developing), aPS/PT
Anti-Neutrophil Cytoplasmic Antibodies MPO, PR3, GBM
Rheumatoid Arthritis CCP (Manufacturing), RF (Manufacturing), MMP3 (Manufacturing), CarP
Autoimmune Hepatitis F-actin, SLA, M2-3E (Manufacturing), GP210 (Developing), SP100, LC-1, LKM-1
Type 1 Diabetes GAD65 (Developing), IA2, IAA, ICA
Membranous Nephropathy PLA2R
PM/DM MDA5, Tifi1γ, NXP2, Jo-1 (Developing), PL-7, PL-12, EJ, OJ, SRP, SSA52, MI-2 (Developing), SAE, pm/scl100, pm/scl75, Ku
Inflammatory Bowel Disease Calprotectin (Manufacturing)
Autoimmune Thyroiditis TRAb\TSHR (Developing)
Others IgG4 Ab (Manufacturing)

* "Manufacturing" indicates that the product has been applied in the production of commercialized assay kits.

* "Developing" indicates that the product is currently in the laboratory stage, awaiting validation for commercialization.

R&D PIPELINE-- INFECTIOUS, ANIMALS, BIOCHEMISTRY

Category Items
Infectious M. pneumonia (Manufacturing), Syphilis, HBs, HCV
Inflammation CRP (Manufacturing), SAA (Manufacturing)
Animals ASFV (Manufacturing), CPV (Developing), FPV (Developing), PRRSV (Developing)
Goat Antiserum IgM (Manufacturing), IgA (Manufacturing), IgG (Manufacturing), C3 (Manufacturing), C4 (Manufacturing)
Others HAMA Blocker (Manufacturing)

* "Manufacturing" indicates that the product has been applied in the production of commercialized assay kits.

* "Developing" indicates that the product is currently in the laboratory stage, awaiting validation for commercialization.

FACILITY-- ON-SITE PICTURES

Facility On-Site Pictures

TECHNICAL PLATFORMS--RECOMBINANT EXPRESSION

Yeast

Vector: pPIC, pPICZ
Host gene: X33, GS15, KM71H, SMD16
Tag: HIS, GST, MBP, SUMO, Trx, secretion signal peptide etc.

Commercialized Proteins:

  • a1-mg: Manufacturing > 4000mg
  • RBP: Manufacturing > 1000mg
  • PA: Manufacturing > 150mg

Mammalian

Vector: 293, CHO
Tag: Light chain kappa, human albumin, human interleukin-2, and green fluorescent protein signaling peptides

Commercialized Proteins:

  • IgG4: Manufacturing > 6000mg
  • HAMA: Manufacturing > 2000gram
  • SAA: Manufacturing > 1000mg
  • D-Dimer: Manufacturing > 100mg

E. Coli

Vector: pET, pGEX及pMAL
Host gene: BL21, BL21(DE3), BL21Plyss(DE3), Rosetta(DE3), Origami B(DE3)
Tag: HIS, GST, MBP, SUMO, Trx, secretion signal peptide etc.

Commercialized Proteins:

  • SAA: Manufacturing > 15 gram
  • CRP: Manufacturing > 30 gram
  • PCNA: Manufacturing > 600mg

TECHNICAL PLATFORMS--SCALE-UP PRODUCTION

Fermentation manufacturing scale-up from 5L-10L-30L-100L.

Fermentation bottles

The site has the capability for the development of recombinant proteins and gram-scale production.

Fermentation equipment

For large-scale prokaryotic expression, we collaborate with universities, while cell expression is outsourced to biopharmaceutical companies.

TECHNICAL PLATFORMS--GOAT IMMUNIZATION

Two cooperative animal facilities in Zhejiang Province, specialize in immunizing mice, rabbits, and goats.

Goat Immunization Capacity:

Currently have approximately 400 immunized goats.

Commercialized Anti-Serum:

  • IgG
  • IgM
  • IgA
  • Apolipoprotein AII
  • Apolipoprotein CII

Developing:

  • Complement C3
  • Complement C4
  • Kappa
  • Lambda
Immunization Process

Mice Immunization Capacity:

Each project has 2-4 specific clones, with approximately 100-500 fusion mice per specific clone.

Commercialized mono-Abs:

  • IgG
  • IgG3
  • IgG4

Developing:

  • IgG1
  • IgG2
  • IgE

TECHNICAL PLATFORMS--RABBIT IMMUNIZATION

Rabbit Immunization Capacity:

Currently have approximately 1000 immunized rabbits.

Commercialized poly-Abs:

  • Serum Amyloid A
  • C-Reactive Protein
  • Calprotectin
  • Retinol-Binding Protein
  • α2-macroglobulin
Rabbit Immunization Process